Induction of triacylglycerol synthesis in yeast by cell cycle arrest.
Identifieur interne : 000320 ( Main/Exploration ); précédent : 000319; suivant : 000321Induction of triacylglycerol synthesis in yeast by cell cycle arrest.
Auteurs : Juliana B. Madeira ; Gabriel S. Matos ; Laryssa S. Messias ; Bruno L. Bozaquel-Morais ; Claudio A. Masuda ; Monica Montero-LomeliSource :
- FEMS yeast research [ 1567-1364 ] ; 2019.
Descripteurs français
- KwdFr :
- Délétion de gène (MeSH), Facteurs de transcription (antagonistes et inhibiteurs), Facteurs de transcription (génétique), Facteurs de transcription (métabolisme), Gouttelettes lipidiques (métabolisme), Homéostasie (MeSH), Mutation (MeSH), Points de contrôle du cycle cellulaire (MeSH), Protein-Serine-Threonine Kinases (génétique), Protéines de Saccharomyces cerevisiae (antagonistes et inhibiteurs), Protéines de Saccharomyces cerevisiae (génétique), Protéines de Saccharomyces cerevisiae (métabolisme), Protéines de liaison à l'ADN (génétique), Régions promotrices (génétique) (MeSH), Régulation de l'expression des gènes fongiques (MeSH), Saccharomyces cerevisiae (génétique), Saccharomyces cerevisiae (métabolisme), Transcription génétique (MeSH), Triglycéride (biosynthèse).
- MESH :
- antagonistes et inhibiteurs : Facteurs de transcription, Protéines de Saccharomyces cerevisiae.
- biosynthèse : Triglycéride.
- génétique : Facteurs de transcription, Protein-Serine-Threonine Kinases, Protéines de Saccharomyces cerevisiae, Protéines de liaison à l'ADN, Saccharomyces cerevisiae.
- métabolisme : Facteurs de transcription, Gouttelettes lipidiques, Protéines de Saccharomyces cerevisiae, Saccharomyces cerevisiae.
- Délétion de gène, Homéostasie, Mutation, Points de contrôle du cycle cellulaire, Régions promotrices (génétique), Régulation de l'expression des gènes fongiques, Transcription génétique.
English descriptors
- KwdEn :
- Cell Cycle Checkpoints (MeSH), DNA-Binding Proteins (genetics), Gene Deletion (MeSH), Gene Expression Regulation, Fungal (MeSH), Homeostasis (MeSH), Lipid Droplets (metabolism), Mutation (MeSH), Promoter Regions, Genetic (MeSH), Protein-Serine-Threonine Kinases (genetics), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae (metabolism), Saccharomyces cerevisiae Proteins (antagonists & inhibitors), Saccharomyces cerevisiae Proteins (genetics), Saccharomyces cerevisiae Proteins (metabolism), Transcription Factors (antagonists & inhibitors), Transcription Factors (genetics), Transcription Factors (metabolism), Transcription, Genetic (MeSH), Triglycerides (biosynthesis).
- MESH :
- chemical , antagonists & inhibitors : Saccharomyces cerevisiae Proteins, Transcription Factors.
- chemical , biosynthesis : Triglycerides.
- chemical , genetics : DNA-Binding Proteins, Protein-Serine-Threonine Kinases, Saccharomyces cerevisiae Proteins, Transcription Factors.
- genetics : Saccharomyces cerevisiae.
- metabolism : Lipid Droplets, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Transcription Factors.
- Cell Cycle Checkpoints, Gene Deletion, Gene Expression Regulation, Fungal, Homeostasis, Mutation, Promoter Regions, Genetic, Transcription, Genetic.
Abstract
In this study, we found that cell cycle arrest induced by alpha-factor mating pheromone (G1), hydroxyurea (S) or nocodazole (G2/M) was associated to increased lipid droplet (LD) content. To identify novel cell cycle genes involved in LD homeostasis, we screened a deletion library for strains with altered LD levels. Among the mutants related to mitotic cell cycle, we found 24 hits that displayed a significantly higher LD content. Ontology mapping showed that neither a biological process nor a specific cell cycle phase was enriched among the hits. We decided to further study the role of SWI4 on LD homeostasis as it is involved in G1/S transition, a stage where lipolysis is active. The high LD content of swi4Δ mutant was not due to inhibition of lipolysis, but due to an increase in triacylglycerol (TAG) synthesis. In addition, deletion of the AMP kinase gene SNF1 or inhibition of TORC1 activity, both known regulators of LD homeostasis, further increased the LD content of a swi4Δ mutant. These findings highlight a role of the cell cycle regulator SWI4 in the coordination of lipid metabolism which is independent of the TORC1 and SNF1/AMPK pathways.
DOI: 10.1093/femsyr/foz030
PubMed: 30985885
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Madeira</name><affiliation><nlm:affiliation>Instituto de Bioquimica Médica Leoplodo de Meis, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho 373, cep 21941-902, Rio de Janeiro, Rio de Janeiro Brazil.</nlm:affiliation><wicri:noCountry code="subField">Rio de Janeiro Brazil</wicri:noCountry></affiliation></author><author><name sortKey="Matos, Gabriel S" sort="Matos, Gabriel S" uniqKey="Matos G" first="Gabriel S" last="Matos">Gabriel S. Matos</name><affiliation><nlm:affiliation>Instituto de Bioquimica Médica Leoplodo de Meis, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho 373, cep 21941-902, Rio de Janeiro, Rio de Janeiro Brazil.</nlm:affiliation><wicri:noCountry code="subField">Rio de Janeiro Brazil</wicri:noCountry></affiliation></author><author><name sortKey="Messias, Laryssa S" sort="Messias, Laryssa S" uniqKey="Messias L" first="Laryssa S" last="Messias">Laryssa S. Messias</name><affiliation><nlm:affiliation>Instituto de Bioquimica Médica Leoplodo de Meis, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho 373, cep 21941-902, Rio de Janeiro, Rio de Janeiro Brazil.</nlm:affiliation><wicri:noCountry code="subField">Rio de Janeiro Brazil</wicri:noCountry></affiliation></author><author><name sortKey="Bozaquel Morais, Bruno L" sort="Bozaquel Morais, Bruno L" uniqKey="Bozaquel Morais B" first="Bruno L" last="Bozaquel-Morais">Bruno L. Bozaquel-Morais</name><affiliation><nlm:affiliation>Instituto de Bioquimica Médica Leoplodo de Meis, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho 373, cep 21941-902, Rio de Janeiro, Rio de Janeiro Brazil.</nlm:affiliation><wicri:noCountry code="subField">Rio de Janeiro Brazil</wicri:noCountry></affiliation></author><author><name sortKey="Masuda, Claudio A" sort="Masuda, Claudio A" uniqKey="Masuda C" first="Claudio A" last="Masuda">Claudio A. Masuda</name><affiliation><nlm:affiliation>Instituto de Bioquimica Médica Leoplodo de Meis, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho 373, cep 21941-902, Rio de Janeiro, Rio de Janeiro Brazil.</nlm:affiliation><wicri:noCountry code="subField">Rio de Janeiro Brazil</wicri:noCountry></affiliation></author><author><name sortKey="Montero Lomeli, Monica" sort="Montero Lomeli, Monica" uniqKey="Montero Lomeli M" first="Monica" last="Montero-Lomeli">Monica Montero-Lomeli</name><affiliation><nlm:affiliation>Instituto de Bioquimica Médica Leoplodo de Meis, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho 373, cep 21941-902, Rio de Janeiro, Rio de Janeiro Brazil.</nlm:affiliation><wicri:noCountry code="subField">Rio de Janeiro Brazil</wicri:noCountry></affiliation></author></analytic><series><title level="j">FEMS yeast research</title><idno type="eISSN">1567-1364</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cell Cycle Checkpoints (MeSH)</term><term>DNA-Binding Proteins (genetics)</term><term>Gene Deletion (MeSH)</term><term>Gene Expression Regulation, Fungal (MeSH)</term><term>Homeostasis (MeSH)</term><term>Lipid Droplets (metabolism)</term><term>Mutation (MeSH)</term><term>Promoter Regions, Genetic (MeSH)</term><term>Protein-Serine-Threonine Kinases (genetics)</term><term>Saccharomyces cerevisiae (genetics)</term><term>Saccharomyces cerevisiae (metabolism)</term><term>Saccharomyces cerevisiae Proteins (antagonists & inhibitors)</term><term>Saccharomyces cerevisiae Proteins (genetics)</term><term>Saccharomyces cerevisiae Proteins (metabolism)</term><term>Transcription Factors (antagonists & inhibitors)</term><term>Transcription Factors (genetics)</term><term>Transcription Factors (metabolism)</term><term>Transcription, Genetic (MeSH)</term><term>Triglycerides (biosynthesis)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Délétion de gène (MeSH)</term><term>Facteurs de transcription (antagonistes et inhibiteurs)</term><term>Facteurs de transcription (génétique)</term><term>Facteurs de transcription (métabolisme)</term><term>Gouttelettes lipidiques (métabolisme)</term><term>Homéostasie (MeSH)</term><term>Mutation (MeSH)</term><term>Points de contrôle du cycle cellulaire (MeSH)</term><term>Protein-Serine-Threonine Kinases (génétique)</term><term>Protéines de Saccharomyces cerevisiae (antagonistes et inhibiteurs)</term><term>Protéines de Saccharomyces cerevisiae (génétique)</term><term>Protéines de Saccharomyces cerevisiae (métabolisme)</term><term>Protéines de liaison à l'ADN (génétique)</term><term>Régions promotrices (génétique) (MeSH)</term><term>Régulation de l'expression des gènes fongiques (MeSH)</term><term>Saccharomyces cerevisiae (génétique)</term><term>Saccharomyces cerevisiae (métabolisme)</term><term>Transcription génétique (MeSH)</term><term>Triglycéride (biosynthèse)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Saccharomyces cerevisiae Proteins</term><term>Transcription Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Triglycerides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA-Binding Proteins</term><term>Protein-Serine-Threonine Kinases</term><term>Saccharomyces cerevisiae Proteins</term><term>Transcription Factors</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Facteurs de transcription</term><term>Protéines de Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Triglycéride</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteurs de transcription</term><term>Protein-Serine-Threonine Kinases</term><term>Protéines de Saccharomyces cerevisiae</term><term>Protéines de liaison à l'ADN</term><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lipid Droplets</term><term>Saccharomyces cerevisiae</term><term>Saccharomyces cerevisiae Proteins</term><term>Transcription Factors</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteurs de transcription</term><term>Gouttelettes lipidiques</term><term>Protéines de Saccharomyces cerevisiae</term><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Cycle Checkpoints</term><term>Gene Deletion</term><term>Gene Expression Regulation, Fungal</term><term>Homeostasis</term><term>Mutation</term><term>Promoter Regions, Genetic</term><term>Transcription, Genetic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Délétion de gène</term><term>Homéostasie</term><term>Mutation</term><term>Points de contrôle du cycle cellulaire</term><term>Régions promotrices (génétique)</term><term>Régulation de l'expression des gènes fongiques</term><term>Transcription génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In this study, we found that cell cycle arrest induced by alpha-factor mating pheromone (G1), hydroxyurea (S) or nocodazole (G2/M) was associated to increased lipid droplet (LD) content. To identify novel cell cycle genes involved in LD homeostasis, we screened a deletion library for strains with altered LD levels. Among the mutants related to mitotic cell cycle, we found 24 hits that displayed a significantly higher LD content. Ontology mapping showed that neither a biological process nor a specific cell cycle phase was enriched among the hits. We decided to further study the role of SWI4 on LD homeostasis as it is involved in G1/S transition, a stage where lipolysis is active. The high LD content of swi4Δ mutant was not due to inhibition of lipolysis, but due to an increase in triacylglycerol (TAG) synthesis. In addition, deletion of the AMP kinase gene SNF1 or inhibition of TORC1 activity, both known regulators of LD homeostasis, further increased the LD content of a swi4Δ mutant. These findings highlight a role of the cell cycle regulator SWI4 in the coordination of lipid metabolism which is independent of the TORC1 and SNF1/AMPK pathways.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30985885</PMID><DateCompleted><Year>2019</Year><Month>12</Month><Day>16</Day></DateCompleted><DateRevised><Year>2019</Year><Month>12</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1567-1364</ISSN><JournalIssue CitedMedium="Internet"><Volume>19</Volume><Issue>3</Issue><PubDate><Year>2019</Year><Month>05</Month><Day>01</Day></PubDate></JournalIssue><Title>FEMS yeast research</Title><ISOAbbreviation>FEMS Yeast Res</ISOAbbreviation></Journal><ArticleTitle>Induction of triacylglycerol synthesis in yeast by cell cycle arrest.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">foz030</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1093/femsyr/foz030</ELocationID><Abstract><AbstractText>In this study, we found that cell cycle arrest induced by alpha-factor mating pheromone (G1), hydroxyurea (S) or nocodazole (G2/M) was associated to increased lipid droplet (LD) content. To identify novel cell cycle genes involved in LD homeostasis, we screened a deletion library for strains with altered LD levels. Among the mutants related to mitotic cell cycle, we found 24 hits that displayed a significantly higher LD content. Ontology mapping showed that neither a biological process nor a specific cell cycle phase was enriched among the hits. We decided to further study the role of SWI4 on LD homeostasis as it is involved in G1/S transition, a stage where lipolysis is active. The high LD content of swi4Δ mutant was not due to inhibition of lipolysis, but due to an increase in triacylglycerol (TAG) synthesis. In addition, deletion of the AMP kinase gene SNF1 or inhibition of TORC1 activity, both known regulators of LD homeostasis, further increased the LD content of a swi4Δ mutant. These findings highlight a role of the cell cycle regulator SWI4 in the coordination of lipid metabolism which is independent of the TORC1 and SNF1/AMPK pathways.</AbstractText><CopyrightInformation>© FEMS 2019.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Madeira</LastName><ForeName>Juliana B</ForeName><Initials>JB</Initials><AffiliationInfo><Affiliation>Instituto de Bioquimica Médica Leoplodo de Meis, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho 373, cep 21941-902, Rio de Janeiro, Rio de Janeiro Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Matos</LastName><ForeName>Gabriel S</ForeName><Initials>GS</Initials><AffiliationInfo><Affiliation>Instituto de Bioquimica Médica Leoplodo de Meis, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho 373, cep 21941-902, Rio de Janeiro, Rio de Janeiro Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Messias</LastName><ForeName>Laryssa S</ForeName><Initials>LS</Initials><AffiliationInfo><Affiliation>Instituto de Bioquimica Médica Leoplodo de Meis, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho 373, cep 21941-902, Rio de Janeiro, Rio de Janeiro Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bozaquel-Morais</LastName><ForeName>Bruno L</ForeName><Initials>BL</Initials><AffiliationInfo><Affiliation>Instituto de Bioquimica Médica Leoplodo de Meis, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho 373, cep 21941-902, Rio de Janeiro, Rio de Janeiro Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Masuda</LastName><ForeName>Claudio A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Instituto de Bioquimica Médica Leoplodo de Meis, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho 373, cep 21941-902, Rio de Janeiro, Rio de Janeiro Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Montero-Lomeli</LastName><ForeName>Monica</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Instituto de Bioquimica Médica Leoplodo de Meis, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho 373, cep 21941-902, Rio de Janeiro, Rio de Janeiro Brazil.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>FEMS Yeast Res</MedlineTA><NlmUniqueID>101085384</NlmUniqueID><ISSNLinking>1567-1356</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004268">DNA-Binding Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C062214">SWI4 protein, S cerevisiae</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D029701">Saccharomyces cerevisiae Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C561842">TORC1 protein complex, S cerevisiae</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014157">Transcription Factors</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014280">Triglycerides</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.1.-</RegistryNumber><NameOfSubstance UI="C071570">SNF1-related protein kinases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber><NameOfSubstance UI="D017346">Protein-Serine-Threonine Kinases</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D059447" MajorTopicYN="Y">Cell Cycle Checkpoints</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004268" MajorTopicYN="N">DNA-Binding Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017353" MajorTopicYN="N">Gene Deletion</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015966" MajorTopicYN="Y">Gene Expression Regulation, Fungal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006706" MajorTopicYN="N">Homeostasis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D066292" MajorTopicYN="N">Lipid Droplets</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011401" MajorTopicYN="N">Promoter Regions, Genetic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017346" MajorTopicYN="N">Protein-Serine-Threonine Kinases</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012441" MajorTopicYN="N">Saccharomyces cerevisiae</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D029701" MajorTopicYN="N">Saccharomyces cerevisiae Proteins</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014157" MajorTopicYN="N">Transcription Factors</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014158" MajorTopicYN="N">Transcription, Genetic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014280" MajorTopicYN="N">Triglycerides</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">AMP-activated protein kinase (AMPK)</Keyword><Keyword MajorTopicYN="Y">Lipid droplet (LD)</Keyword><Keyword MajorTopicYN="Y">Sucrose nonf-fermenting protein kinase (SNF1)</Keyword><Keyword MajorTopicYN="Y">Swi4/Swi6 binding factor (SBF) transcription complex</Keyword><Keyword MajorTopicYN="Y">Target of rapamycin complex 1 (TORC1)</Keyword><Keyword MajorTopicYN="Y">Triacylglycerol</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>11</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>04</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>4</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>12</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>4</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30985885</ArticleId><ArticleId IdType="pii">5462652</ArticleId><ArticleId IdType="doi">10.1093/femsyr/foz030</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list></list><tree><noCountry><name sortKey="Bozaquel Morais, Bruno L" sort="Bozaquel Morais, Bruno L" uniqKey="Bozaquel Morais B" first="Bruno L" last="Bozaquel-Morais">Bruno L. Bozaquel-Morais</name><name sortKey="Madeira, Juliana B" sort="Madeira, Juliana B" uniqKey="Madeira J" first="Juliana B" last="Madeira">Juliana B. Madeira</name><name sortKey="Masuda, Claudio A" sort="Masuda, Claudio A" uniqKey="Masuda C" first="Claudio A" last="Masuda">Claudio A. Masuda</name><name sortKey="Matos, Gabriel S" sort="Matos, Gabriel S" uniqKey="Matos G" first="Gabriel S" last="Matos">Gabriel S. Matos</name><name sortKey="Messias, Laryssa S" sort="Messias, Laryssa S" uniqKey="Messias L" first="Laryssa S" last="Messias">Laryssa S. Messias</name><name sortKey="Montero Lomeli, Monica" sort="Montero Lomeli, Monica" uniqKey="Montero Lomeli M" first="Monica" last="Montero-Lomeli">Monica Montero-Lomeli</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|area= RapamycinFungusV1
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|texte= Induction of triacylglycerol synthesis in yeast by cell cycle arrest.
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